Grapes have been identified as a potential defenders against upper respiratory tract inflammation. A study has shown that the presence of resveratrol in grapes can play a role in managing inflammation triggered by a bacterial pathogen linked to conditions such as chronic obstructive pulmonary diseases (COPD), asthma, and middle ear infections (otitis media). The research highlights how resveratrol can effectively counteract a significant bacterial pathogen responsible for COPD and otitis media by amplifying the production of a negative regulator called MyD88 short.
Resveratrol, categorized as a polyphenol, is part of a group of compounds often considered antioxidants that shield the body from damage. It has been recognized as a potential therapeutic agent for inflammatory diseases. The study specifically showcases resveratrol’s effectiveness in combating inflammation caused by a severe respiratory pathogen known as non-typeable Haemophilus influenzae (NTHi).
Balanced inflammation is a natural defense mechanism against bacterial infections, yet uncontrolled inflammation can lead to inflammatory diseases.
The study’s findings indicate that resveratrol diminishes the expression of pro-inflammatory agents induced by NTHi in both mouse lungs and airway epithelial cells. This reduction is achieved by enhancing MyD88 short, a negative regulator that effectively manages inflammation in airway epithelial cells.
MyD88 short demonstrates its ability to tightly control inflammation triggered by the NTHi pathogen. Furthermore, resveratrol displays anti-inflammatory properties following infection by NTHi.
Written by Damilola Adeleke
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